LYMPHOID NEOPLASIA High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease
نویسندگان
چکیده
1Unit of Recombinant Protein, Institut Pasteur de Montevideo, Montevideo, Uruguay; 2Department of Immunology, Institute for Hematologic Research, National Academy of Medicine, Buenos Aires, Argentina; 3Unit of Cellular Biology, Institut Pasteur de Montevideo, Montevideo, Uruguay; 4Service of Hematology and Bone Marrow Transplantation, Hospital Maciel, Montevideo, Uruguay; 5Institut Pasteur de Montevideo, Montevideo, Uruguay; and 6Unit of Protein Biophysics, Institut Pasteur de Montevideo, Montevideo, Uruguay
منابع مشابه
Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation.
In B cells, somatic hypermutation (SHM) and class switch recombination (CSR) depend on the activation-induced cytidine deaminase (AID) gene product, although the precise mode of action of AID remains unknown. Because some chronic lymphocytic leukemia (CLL) B cells can undergo CSR without SHM, it constitutes a useful model to dissect AID function. In this work, we have studied AID expression, th...
متن کاملChronic lymphocytic leukemia, biology, new diagnosis and treatment: review article
Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
متن کاملIGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.
Clonal evolution occurs during the course of chronic lymphocytic leukemia (CLL) and activation-induced deaminase (AID) could influence this process. However, this possibility has been questioned in CLL because the number of circulating AID mRNA(+) cells is exceedingly low; synthesis of AID protein by blood CLL cells has not been demonstrated; the full range of AID functions is lacking in unmuta...
متن کاملایمونوفنوتایپینگ بیماران مبتلا به لوسمی لنفوسیتی مزمن (CLL) به روش فلوسیتومتری؛ ارتباط با پیش آگهی بیماری
Background and purpose: Chronic lymphocytic leukemia (CLL) is characterized by clonal proliferation and accumulation of long-lived B lymphocytes within the peripheral blood, bone marrow, and secondary lymphoid organs. In this study, immunophenotypic characteristics of leukemic cells and their association with disease prognosis were investigated in CLL patients. Materials and methods: A case-...
متن کاملAID induces intraclonal diversity and genomic damage in CD86+ chronic lymphocytic leukemia cells
The activation-induced cytidine deaminase (AID) mediates somatic hypermutation and class switch recombination of the Ig genes by directly deaminating cytosines to uracils. As AID causes a substantial amount of off-target mutations, its activity has been associated with lymphomagenesis and clonal evolution of B-cell malignancies. Although it has been shown that AID is expressed in B-cell chronic...
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